Apoptosis and cancer drug targeting

Apoptosis and cancer drug targeting.

Apoptosis and Molecular Targeting Therapy in Cancer

Apoptosis is the programmed cell death which maintains the healthy survival/death balance in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals contribute into safeguarding the genomic integrity while defective apoptosis may promote carcinogenesis. The apoptotic signals are complicated and they ar...

Targeting Apoptosis Signaling in Pancreatic Cancer

The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis. Additionally, defective apoptosis signaling is the underlying cause of failure to respond to current treatment approaches, since therapy-mediated antitumor activity requires t...

Targeting apoptosis pathways in cancer--letter.

The review article entitled "Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature" (1) provides a comprehensive listing of the effects of natural products on genes/pathways that result in induction of apoptosis in cancer cells and tumors. Despite the multiple cancer cell context-dependent effects of natural products, the lack of underlying mechanisms...

Targeting apoptosis pathways in cancer therapy.

Apoptosis, or programmed cell death, is a mechanism by which cells undergo death to control cell proliferation or in response to DNA damage. The understanding of apoptosis has provided the basis for novel targeted therapies that can induce death in cancer cells or sensitize them to established cytotoxic agents and radiation therapy. These novel agents include those targeting the extrinsic pathw...